Introducing the FIVE Guide!

5-MeO-DMT is a short-acting and naturally occurring tryptamine psychedelic with powerful entheogenic effects. Interest in use has been skyrocketing in recent years as celebrities endorse that 'smoking Toad venom' has profoundly healing effects, and researchers scramble to develop the next wonder drug for mental health conditions. 

While 5-MeO-DMT shares much pharmacology with other classic tryptamine psychedelics (psilocybin, DMT, LSD) it has notable differences leading to changes in drug interaction potential, particularly with monoamine oxidase inhibitors (MAOIs). 

This guide was put together in a collaborative effort with F.I.V.E. to inform and educate persons interested in 5-MeO-DMT about the pharmacology, drug interaction risks, potential for Serotonin Toxicity, and some risk management or stratification tools when it comes to considering other serotonergic substances. 

Guide Contents

The guide is divided into four main sections which are outlined below:

It seems that I get the most questions about 5-MeO-DMT as there's so little information available about it in general, and there's obviously some really powerful things that come out of its use. I wanted to give something that could help persons gauge risks with 5-MeO-DMT and offer some ideas on how it could differ from classic tryptamine psychedelics. 

This is why I created the Five Guide. I hope you find it of use and service in your psychedelic endeavors. 

Kind regards & blessings on this path,

Ben

Benjamin Malcolm, PharmD, MPH

Spirit Pharmacist